Cinquin Lab

Model organisms

Control of Caenorhabditis elegans germ-line stem-cell cycling speed meets requirements of design to minimize mutation accumulation.

Chiang M., Cinquin A., Paz A., Meeds E., Price C.A., Welling M., Cinquin O. BMC Biology 13:51 (2015) Abstract BACKGROUND: Stem cells are thought to play a critical role in minimizing the accumulation of mutations, but it is not clear…

Live imaging reveals active infiltration of mitotic zone by its stem cell niche.

Wong B.G.‡, Paz A.‡, Corrado M.A., Ramos B.R., Cinquin A., Cinquin O.*, Hui E.E.* Integrative Biology 5(7), pp976-982 (2013)   Abstract Stem cells niches are increasingly recognized as dynamic environments that play a key role in transducing signals that allow…

Phasor approach to fluorescence lifetime microscopy distinguishes different metabolic states of germ cells in a live tissue.

Stringari C., Cinquin A., Cinquin O., Digman M.A., Donovan P.J., Gratton E. PNAS 108(33), pp13582-7 (2011) Abstract We describe a label-free imaging method to monitor stem-cell metabolism that discriminates different states of stem cells as they differentiate in living tissues.…

Progression from a stem cell–like state to early differentiation in the C. elegans germ line

Cinquin O‡*, Crittenden S.L.‡, Morgan D.E., Kimble J*. PNAS 107(5), pp2048-53 (2010) Abstract Controls of stem cell maintenance and early differentiation are known in several systems. However, the progression from stem cell self-renewal to overt signs of early differentiation is…

Purpose and regulation of stem cells: a systems-biology view from the C. elegans germ line.

Cinquin O. J. Pathol. 217, pp186-198 (2009) Abstract Stem cells are expected to play a key role in the development and maintenance of organisms, and hold great therapeutical promises. However, a number of questions must be answered to achieve an…

Understanding the somitogenesis clock: what’s missing?

Cinquin O. Mech. Dev. 124(7-8), pp501-517 (2007) Abstract The segmentation of vertebrate embryos depends on a complex genetic network that generates highly dynamic gene expression. Many of the elements of the network have been identified, but their interaction and their…

A new method to transfect the hypoblast of the chick embryo reveals conservation of the regulation of an Otx2 enhancer between mouse and chick extraembryonic endoderm.

Albazerchi A., Cinquin O., Stern C.D. BMC Dev. Biol. 7:25 (2007) Abstract BACKGROUND: The mouse anterior visceral endoderm (AVE) and the chick hypoblast are thought to have homologous roles in the early stages of neural induction and primitive streak formation.…

Is the somitogenesis clock really cell-autonomous? A coupled-oscillator model of segmentation

Cinquin O., J. Theor. Biol. 222(4), pp459-468 (2003) Abstract A striking pattern of oscillatory gene expression, related to the segmentation process (somitogenesis), has been identified in chick, mouse, and zebrafish embryos. Somitogenesis displays great autonomy, and it is generally assumed…