Cinquin Lab

Chick

Understanding the somitogenesis clock: what’s missing?

Cinquin O. Mech. Dev. 124(7-8), pp501-517 (2007) Abstract The segmentation of vertebrate embryos depends on a complex genetic network that generates highly dynamic gene expression. Many of the elements of the network have been identified, but their interaction and their…

A new method to transfect the hypoblast of the chick embryo reveals conservation of the regulation of an Otx2 enhancer between mouse and chick extraembryonic endoderm.

Albazerchi A., Cinquin O., Stern C.D. BMC Dev. Biol. 7:25 (2007) Abstract BACKGROUND: The mouse anterior visceral endoderm (AVE) and the chick hypoblast are thought to have homologous roles in the early stages of neural induction and primitive streak formation.…

Is the somitogenesis clock really cell-autonomous? A coupled-oscillator model of segmentation

Cinquin O., J. Theor. Biol. 222(4), pp459-468 (2003) Abstract A striking pattern of oscillatory gene expression, related to the segmentation process (somitogenesis), has been identified in chick, mouse, and zebrafish embryos. Somitogenesis displays great autonomy, and it is generally assumed…