Cinquin Lab

Pattern formation

Live imaging reveals active infiltration of mitotic zone by its stem cell niche.

Wong B.G.‡, Paz A.‡, Corrado M.A., Ramos B.R., Cinquin A., Cinquin O.*, Hui E.E.* Integrative Biology 5(7), pp976-982 (2013)   Abstract Stem cells niches are increasingly recognized as dynamic environments that play a key role in transducing signals that allow…

Progression from a stem cell–like state to early differentiation in the C. elegans germ line

Cinquin O‡*, Crittenden S.L.‡, Morgan D.E., Kimble J*. PNAS 107(5), pp2048-53 (2010) Abstract Controls of stem cell maintenance and early differentiation are known in several systems. However, the progression from stem cell self-renewal to overt signs of early differentiation is…

Purpose and regulation of stem cells: a systems-biology view from the C. elegans germ line.

Cinquin O. J. Pathol. 217, pp186-198 (2009) Abstract Stem cells are expected to play a key role in the development and maintenance of organisms, and hold great therapeutical promises. However, a number of questions must be answered to achieve an…

Understanding the somitogenesis clock: what’s missing?

Cinquin O. Mech. Dev. 124(7-8), pp501-517 (2007) Abstract The segmentation of vertebrate embryos depends on a complex genetic network that generates highly dynamic gene expression. Many of the elements of the network have been identified, but their interaction and their…

Is the somitogenesis clock really cell-autonomous? A coupled-oscillator model of segmentation

Cinquin O., J. Theor. Biol. 222(4), pp459-468 (2003) Abstract A striking pattern of oscillatory gene expression, related to the segmentation process (somitogenesis), has been identified in chick, mouse, and zebrafish embryos. Somitogenesis displays great autonomy, and it is generally assumed…