Cinquin Lab

Theoretical papers

Control of Caenorhabditis elegans germ-line stem-cell cycling speed meets requirements of design to minimize mutation accumulation.

Chiang M., Cinquin A., Paz A., Meeds E., Price C.A., Welling M., Cinquin O. BMC Biology 13:51 (2015) Abstract BACKGROUND: Stem cells are thought to play a critical role in minimizing the accumulation of mutations, but it is not clear…

High-dimensional switches and the modeling of cellular differentiation

Cinquin O., Demongeot J., J. Theor. Biol. 233(3), pp391-411 (2005) Abstract Many genes have been identified as driving cellular differentiation, but because of their complex interactions, the understanding of their collective behaviour requires mathematical modelling. Intriguingly, it has been observed…

Is the somitogenesis clock really cell-autonomous? A coupled-oscillator model of segmentation

Cinquin O., J. Theor. Biol. 222(4), pp459-468 (2003) Abstract A striking pattern of oscillatory gene expression, related to the segmentation process (somitogenesis), has been identified in chick, mouse, and zebrafish embryos. Somitogenesis displays great autonomy, and it is generally assumed…