Cinquin Lab

Computational

Control of Caenorhabditis elegans germ-line stem-cell cycling speed meets requirements of design to minimize mutation accumulation.

Chiang M., Cinquin A., Paz A., Meeds E., Price C.A., Welling M., Cinquin O. BMC Biology 13:51 (2015) Abstract BACKGROUND: Stem cells are thought to play a critical role in minimizing the accumulation of mutations, but it is not clear…

Is the somitogenesis clock really cell-autonomous? A coupled-oscillator model of segmentation

Cinquin O., J. Theor. Biol. 222(4), pp459-468 (2003) Abstract A striking pattern of oscillatory gene expression, related to the segmentation process (somitogenesis), has been identified in chick, mouse, and zebrafish embryos. Somitogenesis displays great autonomy, and it is generally assumed…