Cinquin Lab

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A.3 Simulations

Simulations were performed with the Numerical Algorithms Group’s Fortran library Mark 20, using the D03PDF function, called from a custom Fortran 77 program (available on request), compiled with the NAGWare compiler, and run on G5 iMacs and PowerMacs. The D03PDF…

A.2 Evaluation of Gradients

Small dependence of the gradient on the rate of morphogen production has been used as a criterion of biological relevance (Eldar et al., 2003). There are however documented cases of morphogen readouts not being buffered against changes in morphogen production…

A.1 Parameter Values

Table 1: Ranges from which parameters were selected at random for the simulations described in section 3. Parameters Range Distribution Log-uniform 5-30 Uniform Log-uniform Log-uniform Log-uniform log-uniform in Log-uniform , log-uniform in Log-uniform The concentrations of morphogens and receptors, as…

Appendix

Subsections Parameter values Evaluation of gradients Simulations Equations for Wg-like diffusion Equations for Shh-like oligomerization Ranges for the measures plotted in figures 5 and 6

A new method to transfect the hypoblast of the chick embryo reveals conservation of the regulation of an Otx2 enhancer between mouse and chick extraembryonic endoderm. Full Text

Amanda Albazerchi1,2 , Olivier Cinquin1,3 and Claudio D Stern1 1Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT. UK 2Laboratory of Genetics, 425-G Henry Mall, University of Wisconsin, Madison, WI 53706, USA 3Deparment of Biochemistry,…